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Glucuronidation-The critical liver detox pathway

Glucuronidation-The critical liver detox pathway

Glucuronidation is a major phase II pathway for transforming toxins, drugs, and carcinogens into less toxic substances. It is responsible for converting xenobiotics (foreign substances), into water-soluble metabolites that are more easily excreted by the body in the urine or bile. This Phase II transformation/detoxification enzyme system uses glucuronic acid, aka Glucarate to conjugate, and deactivate many drugs and diet-derived constituents. 

The Process of Glucuronidation

1. Glucarate covers cell.
2. Toxins attack cells.
3. Through glucuronidation harmful substances are removed from the cells, made water-soluble, and eliminated from the body.
4. A harmful enzyme often reverses glucuronidation, releasing toxins back into the body.
5. Glucarate from cell bonds with the enzyme, preventing its harmful actions.

Glucarate or Glucuronic Acid is found in small amounts in broccoli, cabbage, Brussels sprouts, as well as apples, grapefruit, and oranges. Given our ever-increasing toxic load, our bodies are not able to keep up with the rate of detoxification needed. Supplementing with an advanced form of Glucarate, also known as D-Glucaric acid (Calcium D-Glucurate), has been shown to support your body’s natural system of detoxification (Glucuronidation). In this way, the body can more readily detoxify things like Bis-Phenol A, Phlatates, Heavy Metals, Mold, Glyphosate, and much other toxics. When paired with muramyl peptide and beta-glucan, the body can more efficiently detoxify. This effect of lowering the toxicity load is measurable in about a three month time period. Ideally, to get a baseline, a toxicity panel should be run before and after this therapy. 

For more information on how to support your Glucuronidation pathway and for more information about how to assess for environmental toxicity, please contact our office.